Laboratory of Systems Biology and Quantitative Pharmacology
Department of Biomedical Engineering
University of Michigan

Research in the Fallahi Lab aims at designing, building and utilizing new experimental and computational tools to analyze multi-scale processes that regulate the behavior of human cells in response to perturbations such as cytokines, stress, cytotoxic and targeted drugs. The lab works at the interface of computational bioengineering, systems biology and quantitative pharmacology, and relies on advanced technologies such as multiplexed proteomic and genomic measurements, high-throughput microscopy, single-cell analysis, and multi-scale modeling. Our long-term goal is to define, at a single-cell level, molecular mechanisms that underlie adaptive cell fate decisions in the presence of cell-autonomous, microenvironment, and therapy-induced selective pressures, and elucidate how they vary under unhealthy conditions, e.g. in cancer cells. A detailed and network-level understanding of these mechanisms will provide a rational basis for choosing the optimal molecular targets to: (i) maximize therapeutic response, (ii) prevent therapeutic resistance, and (iii) reduce therapy-induced adverse effects.